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special instructions
For external use, the drug should not be applied to damaged skin. Cheap piroxicam Avoid contact with the eyes or mucous membranes. In the process of treatment, it is mandatory to monitor the functional state of the liver and the picture of peripheral blood. It is not recommended to use Piroxicam simultaneously with acetylsalicylic acid and other NSAIDs.
Interaction with other drugs:
With the simultaneous use of piroxicam may weaken the action of diuretics and antihypertensive agents.
With the simultaneous use of potassium-sparing diuretics and potassium preparations, hyperkalemia is possible.
With simultaneous use with NSAIDs, corticosteroids, the risk of bleeding from the gastrointestinal tract increases.
With the simultaneous use of lithium salts, an increase in the lithium content in blood plasma is possible.
With simultaneous use with oral anticoagulants, blood coagulation disorders are possible; with acetylsalicylic acid - a decrease in the content of piroxicam in blood plasma.
When using piroxicam 24 hours before or after taking methotrexate, its concentration in the blood plasma increases and toxicity increases.
With simultaneous use with phenytoin, an increase in the concentration of phenytoin in blood plasma is possible; with phenobarbital - a decrease in the concentration of piroxicam in blood plasma is possible; with cimetidine, probenecid, sulfinpyrazone - it is possible to increase the concentration of piroxicam in blood plasma.
Side effects
From the digestive system: often - nausea, loss of appetite, stomatitis, epigastric pain, diarrhea or constipation, flatulence, bleeding gums (due to inhibition of platelet aggregation); in isolated cases - erosive and ulcerative lesions of the gastrointestinal tract with possible bleeding and perforations, a transient increase in the activity of hepatic transaminases, jaundice or fatal liver necrosis. As a rule, these side effects develop with prolonged use in doses of more than 30 mg / day..
From the hemopoietic system: anemia (less commonly aplastic anemia or hemolytic anemia), thrombocytopenia, leukopenia, eosinophilia.
From the side of the central nervous system and peripheral nervous system: dizziness, headache, drowsiness, sleep disturbances, depression, nervousness, hallucinations, mood changes, weakness, sensitivity disorders, eye swelling, visual impairment and signs of eye irritation are possible.
From the side of metabolism: rarely - hyperkalemia, hypo- or hyperglycemia, changes in body weight; in some cases, a transient increase in the content of residual nitrogen and creatinine, uremia along with hyperkalemia.
From the urinary system: acute renal failure (with signs of hemorrhagic vasculitis), acute interstitial nephritis.
Allergic reactions: itching, redness, rash, pemphigus vulgaris, allergic swelling of the skin of the face and hands are possible; in some cases - Stevens-Johnson syndrome, Lyell syndrome; in isolated cases - anaphylactic reactions, bronchospasm, urticaria, angioedema, vasculitis, serum sickness.
Dermatological reactions: rarely - photosensitivity; less commonly - onycholysis, alopecia.
Other: possibly nosebleeds.
Local reactions: possible irritation of the rectal mucosa, tenesmus.
For external use: rarely - erythema and itching at the site of application.
special instructions
Use with caution in case of erosive-ulcerative lesions and bleeding from the gastrointestinal tract in the anamnesis, dyspeptic symptoms, chronic heart failure, impaired liver and kidney function, bronchial asthma, blood coagulation disorders, while prescribing oral anticoagulants, allergic reactions to acetylsalicylic acid and other NSAIDs history.
In the process of treatment, it is necessary to monitor the functional state of the liver and the picture of peripheral blood.
It should not be used externally for violation of the integrity of the skin. Avoid contact with eyes or mucous membranes..
It is not recommended to use piroxicam simultaneously with acetylsalicylic acid and other NSAIDs.
pharmachologic effect
Nonsteroidal anti-inflammatory drug from the group of oxycams. http://www.medicinenet.com/piroxicam/article.htm It has anti-inflammatory, analgesic and antipyretic effects.
The mechanism of action is associated with inhibition of prostaglandin synthesis due to inhibition of cyclooxygenase activity.
It weakens pain. It weakens or suppresses inflammation and pain in joints at rest and during movement, reduces morning stiffness and swelling of joints, helps to increase range of motion.
The analgesic effect occurs 30 minutes after taking the drug inside. The anti-inflammatory effect appears at the end of the first week of treatment. After a single dose, the action lasts for 24 hours.
